Which symptoms are typically associated with chronic kidney disease?

Fatigue, swollen legs, and nausea are indeed common symptoms associated with chronic kidney disease (CKD). As kidney function declines, the kidneys become less efficient at filtering waste products from the blood, which can lead to a buildup of toxins in the body, contributing to feelings of tiredness and fatigue. Swollen legs, or peripheral edema, can occur due to fluid retention, a consequence of the kidneys' decreased ability to excrete excess fluid. Additionally, nausea may arise from the accumulation of urea and other waste products, which can affect the digestive system. These symptoms are reflective of the systemic effects that CKD has on the body as kidney function diminishes over time.

In contrast, chest pain and difficulty breathing can be associated with various cardiovascular conditions and acute events rather than CKD specifically. Increased appetite and hyperactivity are typically not symptoms of kidney disease; rather, they might indicate a different health issue altogether. High energy levels and frequent urination may occur in different contexts, but they are not characteristic of CKD, where individuals generally experience decreased energy and changes in urinary patterns as the disease progresses. Thus, the symptoms listed in the first choice are strongly linked to the manifestations of chronic kidney disease.