Which of the following is NOT a sign of chronic kidney disease?

Chronic kidney disease (CKD) presents with a range of signs and symptoms due to the kidneys' compromised ability to filter waste products and manage fluid balance effectively. The presence of fatigue, frequent urination, and swelling in the ankles are common manifestations of CKD.

Fatigue occurs as a result of anemia, which is frequently seen in CKD due to reduced erythropoietin production. Frequent urination can develop especially in the early stages of CKD when the kidneys are unable to concentrate urine fully, causing an increase in the volume of urine produced. Swelling in the ankles is a symptom of fluid retention and can occur as kidney function declines, leading to issues with regulation of body fluids.

Sudden muscle cramps, while they can occur in various circumstances, are not a defining sign of chronic kidney disease. They are more often associated with other conditions such as electrolyte imbalances or dehydration. In the context of CKD, muscle cramps might happen, but they are not a consistent or recognizable indicator of the disease itself, distinguishing them from the other listed symptoms.